Despite decreasing risks associated with COVID-19 due to vaccines and prior exposure, elderly and immunocompromised individuals remain at elevated risk. Updated vaccines and a new monoclonal antibody, Pemgarda, can provide increased protection for these groups. The CDC has updated guidelines for isolation and recommends multiple doses of the updated vaccines for higher-risk individuals.
Key Points
Elderly and immunocompromised individuals are still at elevated risk of severe COVID-19
CDC recommends multiple doses of updated vaccines for higher-risk groups
Pemgarda is a new monoclonal antibody that may benefit some severely immunocompromised individuals
Pros
Updated COVID-19 vaccines and monoclonal antibody Pemgarda provide increased protection for elderly and immunocompromised individuals
CDC guidelines have been updated to provide better protection strategies for high-risk groups
Rates of COVID-19-associated hospitalization have declined across adult age groups
Cons
Cost and logistics challenges associated with the new monoclonal antibody Pemgarda
Not all severely immunocompromised people may have access to Pemgarda
Challenges in predicting the immune response of immunocompromised individuals to vaccination