Senescent Cells and Aging Process
Scientists are developing treatments to target senescent cells, which are linked to accelerated aging in childhood cancer survivors. Senolytics, drugs that eliminate senescent cells, are being tested to improve physical function and extend lifespan. Some researchers are exploring an 'ageing vaccine' to selectively remove harmful senescent cells. While promising, caution is advised as senescent cells are just one aspect of the aging process.
Key Points
- Senescent cells are linked to accelerated aging in childhood cancer survivors.
- Senolytics like dasatinib and quercetin are being tested to eliminate senescent cells and improve physical function.
- An 'ageing vaccine' using GPNMB protein selectively targets harmful senescent cells.
- Caution is advised as senescent cells are just one piece of the aging puzzle.
Pros
- Development of treatments targeting senescent cells could improve physical function and potentially extend lifespan.
- Senolytics have shown promise in preclinical studies and are being tested in clinical trials for various age-related diseases.
Cons
- Clearing all senescent cells indiscriminately could have negative consequences as some of these cells play important roles in physiological functions.
- Further research is needed to understand the long-term effects of senolytics and 'ageing vaccines' on humans.